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Mania and Bipolar Disorder

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Terms: Manic symptoms (9,332), bipolar disorder (674,865), mood stabilizers (24,605), anti-psychotic (30,544), antipsychotic (132,782), effect on manic (23), racing thoughts (19,938), sleep difficulty (1,932), mixed episode (1,661), core symptoms (9,332), control mania (548), cognition (1,195,115), concentration (7,899,794), insight (11,900,005), ability to concentrate (87,319), bipolar episode (135), improving cognition (415), impulsive behavior (25,453), blood monitoring (7,211), weight gain (1,086,976),

Terms: atypical antipsychotic (16,403), atypical antipsychotics (17,746), olanzapine (45,887), zyprexa (71,481), risperdal (57,694), seroquel (34,362), clozapine (51,048), risperidone (64,340), quetiapine (20,150), ziprasidone (10,252), sertindole (1,871), chlorpromazine (28,510), haloperidol (113,975), pharmacokinetics (231,202), pharmacoeconomics (19,989), neuroleptic (25,199), neuroleptics (41,927),

Terms: serotonin syndrome (18,807), serotonergic agents (1,425), risk factors (1,879,242), Vicki Ellingrod (70),

PubMed: zyprexa (1,022),

Tissue distribution of olanzapine in a postmortem case. Merrick TC, Felo JA, Jenkins AJ. Am J Forensic Med Pathol. 2001 Sep;22(3):270-4.  In the brain, the following distribution of olanzapine was determined (mg/kg): negative (cerebellum), 0.22 (hippocampus), 0.86 (midbrain), 0.16 (amygdala), 0.39 (caudate/ putamen), 0.17 (left frontal cortex), and 0.37 (right frontal cortex).

Comparison of cost, dosage and clinical preference for risperidone and olanzapine.Rabinowitz J, Lichtenberg P, Kaplan Z.  Schizophr Res. 2000 Dec 15;46(2-3):91-6.  Risperidone has a substantial cost advantage over olanzapine, and was preferred by psychiatrists for more indications.

A comparative effectiveness study of risperidone and olanzapine in the treatment of schizophrenia. Ho BC, Miller D, Nopoulos P, Andreasen NC. 
J Clin Psychiatry. 1999 Oct;60(10):658-63. Risperidone and olanzapine were equally effective as acute treatments. Risperidone was more effective for [long term > 6 months] treatment of psychotic symptoms.